![]() Phlebotomy was performed at enrollment, and plasma specimens cryopreserved. 18, 19, 28 Intermediate-stage AMD was graded at the reading center as previously described. Computer software measured the caliber of the individual vessels, then combined them into two summary measures: the central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE). Briefly, the six largest arterioles and six largest venules in a ring-shaped area located between 0.5 and 1.0 disc diameters from the edge of the optic nerve were identified. Retinal vascular indices were determined using previously-described semi-automated methods. 18, 19, 28 As part of a study of AMD, mortality, and biomarkers of systemic inflammation, participants with AMD at enrollment were matched on decade of age, race/ethnicity-, and sex with 2 controls from LSOCA for a case control study, 29 resulting in a study population of 454 persons with AIDS. 27 Baseline photographs were taken on all participants and evaluated for retinal vascular caliber at the Reading Center in the Department of Ophthalmology and Visual Sciences at the University of Wisconsin, Madison, School of Medicine and Public Health by graders masked as to clinical data, as previously described. The Longitudinal Study of the Complications of AIDS was a prospective cohort study of patients with the acquired immunodeficiency syndrome conducted in the era of modern ART. Therefore, we evaluated the relationship between several biomarkers of systemic inflammation and retinal vascular caliber in persons with AIDS enrolled in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA). 20 – 24 Elevated blood levels of C-reactive protein (CRP) a biomarker of systemic inflammation, are a risk factor for the development of AMD in HIV-uninfected persons, 25 and persons with AMD have elevated blood levels of several proinflammatory cytokines, 26 suggesting that systemic inflammation might be a common pathogenetic factor in both processes. ![]() 19 Retinal venular dilation is associated with systemic inflammation in HIV-uninfected persons. 18 Although a decline in retinal vascular caliber is associated with increasing age, persons with AIDS and AMD have dilated retinal arterioles and venules compared to persons with AIDS without AMD. 17 Retinal vascular caliber declines with age, and persons with AIDS have retinal arteriolar and venular calibers comparable to HIV-uninfected persons ∼10 years older. 13 – 15Ĭonsistent with this accentuated/accelerated aging, persons with AIDS have an ∼4-fold increased age- and sex-adjusted prevalence of intermediate-stage AMD compared to HIV-uninfected persons 16 and a ∼1.75-fold increased race/ethnicity- and sex-adjusted incidence of intermediate-stage AMD compared to HIV-uninfected persons. 9 – 12 Compared to HIV-uninfected persons, those with HIV infection have persistently high levels of immune activation and systemic inflammation, despite ART-mediated viral suppression, particularly those who initiate ART at advanced stages of HIV disease. 9, 10 They also exhibit features of immunosenescence, a state characterized by chronic immune activation and systemic inflammation, but a poor response to new antigenic challenges. 5, 6 They have an increase is age-related diseases such as cardiovascular disease, metabolic disorders (e.g., diabetes and osteoporosis), neurocognitive decline, and age-related cancers not associated with AIDS, 7 – 10 suggesting accentuated and accelerated aging. 1 – 4 Nevertheless, they have a shortened lifespan compared to comparably aged HIV-uninfected persons, largely due to age-related diseases. Human immunodeficiency virus (HIV)-infected persons treated with modern antiretroviral therapy (ART) have suppressed HIV replication, reduced amounts of HIV RNA circulating in the blood (HIV viral load), improved immune function typically manifested as a rise in CD4+ T cells (immune recovery), decreased opportunistic infections, and an improved lifespan.
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“I especially want to recognize the Black women and other women of color who excelled in every department at ‘ABLSS.’ I am also eternally grateful for the support of Issa Rae and Jax Media, Amy Gravitt, Casey Bloys and the entire team at HBO, Max and Warner Bros. ![]() ![]() “Thank you to all the immensely talented cast members, guest stars, writers, directors, editors and crew members who have made ‘A Black Lady Sketch Show’ an Emmy-winning success,” Thede said in a statement to Variety. Veterans of the show include “Abbott Elementary’s” Emmy-winning creator and star Quinta Brunson, “Ted Lasso” Emmy winner Ashley Nicole Black and “iCarly” reboot star Laci Mosley. Even when the subject matter had nothing to do with Blackness, the show’s very existence was impactful.įor the series’ fourth season, which debuted in April, Thede starred alongside core cast members Gabrielle Dennis and Skye Townsend, joined by featured players DaMya Gurley, Tamara Jade and Angel Laketa Moore. “Robin, alongside Hoorae, Jax Media, and the incredible cast and crew, leave an indelible legacy not only in sketch, but in television comedy, and we look forward to continued creative collaboration under her deal with us.”Ĭreated by Thede, who also served as showrunner, executive producer and writer, “A Black Lady Sketch Show” framed the world in a Black woman’s point of view with sketches that subverted traditional expectations and riffed on relatable themes - like hair woes, ashy skin and the politics of the Black church. ![]() “For four exceptional seasons of ‘A Black Lady Sketch Show’ we’ve been thrilled to partner with her on this groundbreaking, hilarious series,” representatives for the network said of Thede. 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A call to a task force tip line alerted investigators to the two men.Īgencies involved in the arrests included the DPS FBI ATF Tyler Police Department, Henderson County Sheriff's Office and Fire Department Van Zandt County Sheriff's Office and Fire Department Wills Point Police Department Smith County Sheriff's Office, Fire Department and Fire Marshal's Office Athens Police Department and the Canton Police Department. The task force includes hundreds of local law enforcement officers, more than 200 personnel from the DPS, including Texas Rangers, Highway Patrol troopers and Criminal Investigation Division agents, fixed-wing and helicopter aviation assets and the DPS Communications and Fusion Centers, and numerous FBI and Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF) agents and specialists. The men were arrested by the task force created to find these individuals and stop these arsons. "Clearly this effort shows that Texas law enforcement has mastered the art and science of working together, sharing information, and dedicating the necessary resources to bring cases such as these to a successful resolution, and these officers are to be commended," McCraw said. McCraw, director of the Texas Department of Public Safety. The arsons of these houses of worship were despicable and cowardly acts, and Texas won't stand for this kind of criminal activity," said Steven C. "By working closely with our local and federal partners, we brought tremendous resources to this investigation, working around the clock, and culminating in these arrests. ![]() Bourque was arrested without incident in Van Zandt County and transported to Smith County and McAllister was arrested without incident by Texas Rangers in San Antonio and also transported to Smith County. They had attended the First Baptist Church in Ben Wheeler together. The two men arrested are Jason Robert Bourque, 19, of Lindale and Daniel George McAllister, 21, of Ben Wheeler. Three other churches were targets of attempted break-ins, and investigators believe those and the remaining nine burned churches are also connected to these men. The following was released by the Texas Department of Public Safety:Īuthorities have charged and arrested two men in connection with one of the 10 church arson fires that occurred in East Texas beginning on Jan. Another important piece of information announced at Sunday's press conference is that the fire at Little Hope Baptist Church in Canton has been ruled as arson, raising the total number of church arsons in East Texas since the beginning of the year from nine to 10. ![]() FTP stimulates the users to download, rename, upload, delete files, and many more. It just works.If you are looking for the best free FTP Clients for Windows 11, 10, 8, and 7 PC then you are on the right page. 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With platforms like YouTube, Facebook, and LinkedIn supporting video content, marketers have a plethora of avenues to reach their target audience. In the digital era, where attention spans are dwindling, video has proved to be a powerful tool for capturing viewer attention.įrom promoting products to building brand awareness, video content helps connect with audiences on a deeper level, driving customer engagement and conversion rates. Video production has become an integral part of marketing strategies. The Role of Video Production in Marketing ![]() ![]() Social Media Videos: designed for platforms like Instagram and Facebook.Įach video type serves a specific purpose and caters to a specific audience. They can be used to promote the event or share highlights after the event is over. They can be used to help employees understand the company’s processes and procedures.Įvent Videos: Event videos are used to document events such as conferences, conventions, and other gatherings. Training Videos: Training videos are used to teach employees how to use a product or service. They can be used to help customers get the most out of a product or service. Tutorial Videos: Tutorial videos are used to explain how to use a product or service. They’re often used to introduce a product or service to potential customers. These videos can be used on websites, social media, and other digital platforms.Įxplainer Videos: Explainer videos break down complex subjects into digestible content. Marketing Videos: Marketing videos are used to promote a product or service. Given the diversity of the target audience and their unique interests, a variety of video types have emerged. Each stage serves a unique purpose in the journey from the initial concept to the final product. This process comprises three main stages: pre-production, production, and post-production, which includes the editing process. Video production and film production each highlight different aspects of visual storytelling while filmmaking traditionally focuses on the artistic endeavor of creating cinema, video production extends its reach to diverse formats like commercials, corporate videos, and digital content. Traditionally, this referred to the use of video tapes instead of on film stock, however, today’s definition also includes images recorded digitally. Video production is the process of creating video content – akin to filmmaking or film production. The process of producing a video is crucial in creating captivating content, whether it is for a popular musician’s music video or a multinational corporation’s promotional video. It’s not just about recording visuals it’s a meticulous process that involves planning, shooting, and editing to create a final product that resonates with the audience. Those “old school” methods, from a few months ago, are laughable when you see how far AI has progressed in such a short amount of time.Creating a compelling story using a video camera is called video production. In 2022, one of the first public AI video generators simply superimposed tiny AI images over stock footage. Just months ago, we were teased with glimpses of the potential of similar videos created in AI labs. The rapid pace of AI innovation is phenomenal. poli from multimodal art MaFast-paced innovation With diffusers you can control how long the video is – and fit it on smol VRAM GPUs, including free colab. You maybe saw fun junky text-to-video from the ModelScope's research model lately Fast & longer text-to-video with □ diffusers By not reading it first, you decided that the time the moderators and members spent contributing to the wiki was beneath you. Any posts that are confusing, low quality, or lazy such as only saying Title in the body text, will be discarded.ĭon't post questions already answered.Quit spamming the same issues, contentious politics, & misinformation.Harassment of others, as well as insulting remarks & inappropriate behavior, will result in a permanent ban without warning.Do not encourage rule breaking by asking which specific title another person is looking for when they make a request.ĭon't harass others, spam, or submit low-quality posts.No, you may not ask for a specific pirated title (eg. ![]() No, you may not link to a specific pirated title ( eg.Yes, you can link to the top level domain of a site ( eg.No self-promotion of your own work is allowed unless you expressly receive permission from the moderators.ĭon't request or link to specific pirated titles.No trading or selling content, especially not for monetary services.No asking for content downloads, activation keys, giveaways etc. ![]()
![]() Trello might be a better deal for the least expensive of the paid plans, but when it comes to the free versions, we are giving this award to ClickUp because of the unlimited number of users and the real-time chat, whiteboard and native time tracking. There is also a little customization for the interface.ĬlickUp’s free plan offers 100 MBs of storage, unlimited tasks, unlimited number of users, real-time chat, collaboration tools and a whiteboard, among other things. You can run up to 250 workspace commands per month for free. You get unlimited storage but with a 10 MB file max. Trello’s free version gets you unlimited cards but not unlimited boards. For example, most of ClickUp’s awesome tools like advanced time tracking are in the more expensive paid plans. We feel there is more bang for your buck at the lower end of the pricing options with Trello over ClickUp. You get unlimited boards beginning in Trello’s standard plan. The first is a free plan, and the standard plan, premium plan and enterprise plan are reasonably priced after that. The first is free, and the unlimited plan, business plan and business plus plan are reasonably priced, after that there is an enterprise plan with custom pricing. Top competitor for QuickBooks if you need templatesĬlickUp has 5 pricing plans. Great replacement for QuickBooks for ease of use Good alternative to QuickBooks if you want profit loss analysis Good QuickBooks substitute for tax planning ![]() $15 per organization per month billed annually Top QuickBooks competitor for startups and small business Good QuickBooks alternative if you run large business or enterpriseĬheaper alternative to QuickBooks if you’re on a budget Let’s take a quick glance at this overview of our ClickUp vs Trello ratings. ClickUp alternatives generally need to offer something special or undercut ClickUp’s price tag. Your typical ClickUp review will generally comment on the fact that ClickUp is a very thorough and robust PM system yet still manages to be relatively affordable. Alternatives to Trello often attempt to copy some of Trello’s basic interface and tools. Many Trello reviews comment on how simple and straightforward Trello is for creating projects and managing tasks. Trello is made by software company Atlassian. Which one is more suitable for your project or organization? Read on! ClickUp, on the other hand, is mostly about unifying project management, team collaboration and document management. The main difference between Trello and ClickUp is that Trello is a task management tool which relies on a Kanban-board like system. What is the difference between ClickUp and Trello? ![]() Next, we’ll look at some of the specific features of these project management software solutions. Both of these are among the best project management platforms on the market, especially for small teams and small businesses.įirstly, we’ll describe each software, then compare some of the basics like pricing, free plans, customer service and ease of use. In this article, we’ll be comparing ClickUp vs Trello. ![]() applies additional semantics to column types mapping them directly to. As described in Data types, doesn't try to hide the underlying quirkiness of SQLite, which allows any arbitrary string to be specified as the column type, and only has four primitive types: INTEGER, REAL, TEXT, and BLOB. The biggest difference between and is how data types are handled. We try, when possible, to minimize changes between the two to ease transitioning between them. ![]() When new features are added to, the design of is taken into account. See ADO.NET limitations for details about ADO.NET APIs not implemented by. The original goal of to be lightweight and modern, however, still remains. Like it did for many others, this unblocked allowing it to also be ported to. Many of the removed APIs, including the DataSet APIs, were added back. NET Framework was vital to the success of. NET Core 2.0 experienced a change in strategy. (Func)((object args) => Math.Ceiling((double)((object)args))), ![]() New SQLiteFunctionAttribute("ceiling", 1, FunctionType.Scalar), NET Core.Īs an example of what we mean by more modern, here is code to create a user-defined function in both and. This would allow them to create a new lightweight and modern implementation that would align with the goals of. After a long discussion, the Entity Framework team decided to create based on Brice's prototype. Brice was also experimenting with his own implementation of a SQLite ADO.NET provider around the same time that. Brice Lambson, a member of the EF team, had previously helped the SQLite team add support for Entity Framework versions 5 and 6. The Entity Framework team was somewhat familiar with the codebase. ADO.NET didn't include any of the DataSet APIs (including DataTable and DataAdapter). Obsolete APIs and APIs with more modern alternatives were intentionally removed. NET Core (released in 2016) was a single, lightweight, modern, and cross-platform implementation of. NET Framework back to version 2.0 and even. New releases continue to ship assemblies compatible with every version of. has a long history and has evolved into a stable and full-featured ADO.NET provider complete with Visual Studio tooling. It's also worth noting that the Mono team forked the code in 2007 as. In 2010, the SQLite team took over maintenance and development of the project. In 2005, Robert Simpson created, a SQLite provider for ADO.NET 2.0.
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